| CAS NO: | 83314-01-6 |
| 包装: | 10 μg |
| 市场价: | 5200元 |
| 生物活性 | Bryostatin 1 is a naturalmacrolideisolated from the bryozoanBugula neritinaand is a potent and central nervous system (CNS)-permeablePKCmodulator. Bryostatin 1 binds to the isolated C1 domain ofMunc13-1and the full-lengthMunc13-1protein withKis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1infectionproperties[1][2][3][4]. | |||||||||
| IC50& Target |
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| 体外研究 (In Vitro) | Bryostatin 1 (1 μM; 5 minutes; HT22 cells) treatment successfully recruits Munc13-1 from the cytosol to the plasma membrane. Effects of Bryostatin 1 on the other Munc13 family members, ubMunc13-2 and bMunc13-2, resembled those of Munc13-1 for translocation[1]. Western Blot Analysis[1]
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| 体内研究 (In Vivo) | Bryostatin 1 (30 μg/kg; intraperitoneal injection; 3 d per week; for 2 weeks; C57BL/6J mice) treatment abolishes the onset of EAE[2].
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| Clinical Trial | ||||||||||
| 分子量 | 905.03 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C47H68O17 | |||||||||
| CAS 号 | 83314-01-6 | |||||||||
| 中文名称 | 苔藓抑素1 | |||||||||
| 结构分类 |
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| 来源 | Bugula neritina | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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