CAS NO: | 93076-98-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | R 59-022 (DKGI-I) hydrochloride is aDGKinhibitor (IC50: 2.8 μM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a5-HT Receptorantagonist, and activatesprotein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[1][2][3][4]. | ||||||||
IC50& Target[4] |
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体外研究 (In Vitro) | R 59-022 (10 μM,1 分钟) hydrochloride 增强聚集,但不会增强由次最大浓度的凝血酶引起的形状变化[2]。 Western Blot Analysis[4]
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体内研究 (In Vivo) | R 59-022 (2 mg/kg,腹腔注射,12 天) hydrochloride 显着增加植入 U87 GBM 细胞的 SCID 小鼠的中位生存期[6]。
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分子量 | 496.04 | ||||||||
Formula | C27H27ClFN3OS | ||||||||
CAS 号 | 93076-98-3 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |