Cannabisin F

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Cannabisin F

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	163136-19-4
包装:	1mg
市场价:	4900元

产品介绍

Cannabisin F 是一种SIRT1调制器。Cannabisin F 作为大麻籽木素酰胺，可用于抗炎、抗氧化研究。Cannabisin F 作为SIRT1/NF-κB 和 Nrf2 的调节因子，可能是一种潜在的神经退行性疾病的调节剂。

生物活性

Cannabisin F is aSIRT1modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2^[1].

IC₅₀& Target

SIRT1^[1]

体外研究
(In Vitro)

Cannabisin F (0~15 μM; 1 hour; BV2 microglia cells) inhibits the phosphorylation of IκBα, p65, but enhances the expression of Nrf2 and HO-1^[1].
Cannabisin F (0~15 μM; 24 hours; BV2 microglia cells) has no significant effect on cell survival, inhibits IL-6 and TNF-α production and their mRNA expression, inhibits the production of ROS and increases the expression of SIRT1^[1].

Cell Viability Assay^[1]

Cell Line:	BV2 microglia cells
Concentration:	0~15 μM
Incubation Time:	24 hours
Result:	Had no significant effect on cell survival.

Western Blot Analysis^[1]

Cell Line:	BV2 microglia cells
Concentration:	0~15 μM
Incubation Time:	1 hour
Result:	Inhibited the phosphorylation of IκBα, p65, but enhanced the expression of Nrf2 and HO-1.

分子量

624.68

Formula

C₃₆H₃₆N₂O₈

CAS 号

163136-19-4

结构分类

Phenols
Monophenols

来源

Plants
Solanaceae
Datura metelLinn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.