CAS NO: | 1105698-15-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Salermide is an inhibitor ofSirt1andSirt2; can cause strong cancer-specific apoptotic cell death. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | Salermide shows a dose-dependent inhibition that rises to 80% at 90 μM and 25 μM against Sirt1 and Sirt2, respectively. Salermide can prompt tumour-specific cell death in a wide range of human cancer cell lines derived from leukaemia (MOLT4, KG1A, K562), lymphoma (Raji), colon (SW480) and breast (MDA-MB-231). Incubation with 100 μM Salermide alone resulted in an increase of cytosolicactivated caspase 3 and a decrease of mitochondrialcytochrome. Salermide alone can induce apoptosis through both extrinsic and intrinsic pathways. Salermide had several antitumorigenic advantages over the earlier described class III HDAC inhibitors: firstly, it mimics the universal proapoptotic effect on cancer samples exhibited by the classical class I, II and IV HDAC inhibitors, and secondly, its proapoptotic effect is cancer-specific[1]. | ||||||||||||||||
体内研究 (In Vivo) | Salermide is well tolerated by mice at concentrations up to 100 μM. Salermide's mechanism of actionin vivois specifically mediated by Sirt1. Intraperitoneal feeding of Salermide has no apparent toxicity in nude mice[1]. | ||||||||||||||||
分子量 | 394.47 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C26H22N2O2 | ||||||||||||||||
CAS 号 | 1105698-15-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 50 mg/mL(126.75 mM) *"≥" means soluble, but saturation unknown. 配制储备液
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以下溶剂前显示的百
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