SIRT5 inhibitor 5 是一种有效的SIRT5抑制剂,IC50值为 0.21 μM。SIRT5 inhibitor 5 不占据 NNAD+结合口袋,作为底物竞争性抑制剂。
生物活性 | SIRT5 inhibitor5 is a potentSIRT5inhibitor with anIC50value of 0.21 μM.SIRT5 inhibitor5 does not occupy the NNAD+-binding pocket and acts as a substrate-competitive inhibitor[1]. |
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体外研究 (In Vitro) | SIRT5 inhibitor 5 (compound 47) (0-10 μM) 在不同浓度的 NAD+(50, 100, 200, 400, 800 μM) 中显示抑制活性没有显着变化,在 Ac-K(Suc)-AMC(10、30、90、270 μM)浓度增加的情况下降低了抑制活性[1]。
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |