DU125530

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DU125530

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

161611-99-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

DU125530 是一种有效的选择性5-HT1A 受体拮抗剂，对 5-HT1A、5-HT1B、5-HT1D、5-HT2A、5-HT2C、5-HT3 的K_i值分别为 0.7、890、1200、240、750、1100 nM。DU125530 具有抗抑郁作用。

生物活性

DU125530 is a potent and selective5-HT1A receptorantagonist withK_ivalues of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects^[1]^[2].

IC₅₀& Target^[1]

5-HT_1AReceptor

0.7 nM (Ki)

5-HT_1BReceptor

890 nM (Ki)

5-HT_1CReceptor

1200 nM (Ki)

5-HT_2AReceptor

240 nM (Ki)

5-HT_2CReceptor

750 nM (Ki)

5-HT₃Receptor

1100 nM (Ki)

体内研究
(In Vivo)

DU125530 (3 mg/kg; s.c.) 在野生型小鼠中的降低8-OH-DPAT(HY-112061) 诱导的 5-HT 释放的减少^[1]。

Animal Model:	wild-type mice^[2]
Dosage:	3 mg/kg
Administration:	S.c.
Result:	Prevented the reduction of 5-HT release induced by 0.5 mg·kg–1 s.c. 8-OH-DPAT in WT mice, alone had no effect on the extracellular 5-HT concentration in mPFC of wild-type mice (WT) nor in 5-HT1A receptor knock-out mice (KO).

分子量

491.99

Formula

C₂₃H₂₆ClN₃O₅S

CAS 号

161611-99-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.