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Oleyl Trifluoromethyl Ketone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Oleyl Trifluoromethyl Ketone图片
CAS NO:177987-23-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
potent inhibitor of FAAH
Cas No.177987-23-4
别名Heptadecyl Trifluoromethyl Ketone,OTK
化学名1,1,1-trifluoro-10Z-nonadecen-2-one
Canonical SMILESCCCCCCCC/C=C\CCCCCCCC(=O)C(F)(F)F
分子式C19H33F3O
分子量334.5
溶解度≤25mg/ml in DMSO;25mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor [1][2].

Fatty acid amide hydrolase (FAAH) is a member of the serine hydrolase family of enzymes. FAAH is the principal catabolic enzyme for the fatty acid amides (FAAs) that hydrolyzes both oleamide and anandamide as well as several other fatty acid amides [2].

Oleyl Trifluoromethyl Ketone is an analog of oleic acid in which the COOH group is replaced by trifluoromethyl ketone. Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor in both human and rat. In transfected COS-7 cells, 10 μM oleyl trifluoromethyl ketone inhibited hydrolysis of oleamide by human and rat FAAH activities by 95.7% and 94.8%, respectively [2].

References:
[1].  Cravatt BF, Giang DK, Mayfield SP, et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature. 1996 Nov 7;384(6604):83-7.
[2].  Giang DK, Cravatt BF. Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42.