CAS NO: | 1221416-42-7 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Relenopride (YKP10811) hydrochloride is a specific and selective5-HT4receptoragonist (Ki=4.96 nM). Relenopride hydrochloride has 120-fold and 6-fold lower affinity, respectively, for 5-HT2A(Ki=600 nM) and 5-HT2Breceptors (Ki=31 nM) than for 5-HT4. Relenopride hydrochloride increases gastrointestinal (GI) motility[1][2]. | ||||||||||||||||
IC50& Target[1] |
| ||||||||||||||||
体外研究 (In Vitro) | Relenopride hydrochloride do not show any significant off-target binding to any other receptors, enzymes, orserotonin-receptor subtypes at 1 μM, except for binding to the 5-HT2Areceptor and the 5-HT2Breceptor. Relenopride hydrochloride shows antagonist activity at the 5-HT2Breceptor with an IC50of 2.1 μM and no significant activity at the 5-HT2Areceptor up to 10 μM. Relenopride hydrochloride shows no activity against serotonin-receptor subtypes 5-HT1B, 5-HT1D, or 5-HT2Aat 1 nM to 10 μM, or for serotonin-receptor subtype 5-HT7at 10 nM to 30 μM[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 529.43 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H31Cl2FN4O4 | ||||||||||||||||
CAS 号 | 1221416-42-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 110 mg/mL(207.77 mM;Need ultrasonic) H2O : 50 mg/mL(94.44 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
|