5-Carboxamidotryptamine (5-CT) 是一种5-HT1A, 5-HT1B, 5-HT1D, 5 -HT5A, 5-HT7受体激动剂。5-Carboxamidotryptamine 对克隆的人 5-HT5A受体的Ki值为 4.6 nM。5-Carboxamidotryptamine 导致小鼠直肠温度的剂量依赖性降低。
| 生物活性 | 5-Carboxamidotryptamine (5-CT) is a5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7receptor agonist[1][2][3][4]. 5-Carboxamidotryptamine has aKivalue of 4.6 nM for cloned human 5-HT5Areceptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice[3][4]. |
| IC50& Target[1][2][3][4] | 5-HT1AReceptor | 5-HT1BReceptor | 5-HT1DReceptor | 5-HT5AReceptor | 5-HT7Receptor |
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体内研究
(In Vivo) | 5-Carboxamidotryptamine (0.03-3 mg/kg i.p. and 0.125-5 μg i.c.v.) causes a dose-dependent reduction in rectal temperature of mice[3].
5-Carboxamidotryptamine (0.1-1 mg/kg; i.p.) reduces rectal temperature in wild type mice but not 5-HT7receptor knockout mice[3].
5-Carboxamidotryptamine (0.0 1-1 μg/kg; i.v.) causes consistent, dose-related decreases in diastolic blood pressure and carotid arterial vascular resistance and increases in heart rate of cats. In contrast, 5-HT (1-100 μg/kg; i.v.) causes tachycardia but variable and complex effects on diastolic blood pressure and carotid arterial vascular resistance[5].
5-Carboxamidotryptamine does not cause bronchoconstriction in cats. In contrast, 5-HT causes dose-related bronchoconstriction[5].
| Animal Model: | Male Swiss Webster mice (20-25 g)[3] | | Dosage: | 0.03-3 mg/kg (i.p.) and 0.125-5 μg (i.c.v.) | | Administration: | i.p. and i.c.v. | | Result: | Caused dose-dependent reduction in rectal temperature. |
| Animal Model: | 5-HT7receptor knockout mice (background=50% 129SvEv/50% C57Bl/6J)[3] | | Dosage: | 0.1-1 mg/kg | | Administration: | i.p. and i.c.v. | | Result: | Reduced rectal temperature in wild type but not 5-HT7receptor knockout mice. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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