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PNU-282987 free base
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PNU-282987 free base图片
CAS NO:711085-63-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PNU-282987 (free base) 是一种有效的 α7 烟碱乙酰胆碱受体 (nAChR) 激动剂,EC50为 154 nM。 PNU-282987 (free base) 也是 5-HT3受体的功能性拮抗剂,IC50为 4541 nM。PNU-282987 (free base) 可用于中枢和外周神经系统的研究。
生物活性

PNU-282987 (free base) is a potentα7 nicotinic acetylcholine receptor (nAChR)agonist with anEC50of 154 nM. PNU-282987 (free base) is also a functional antagonist of the5-HT3receptorwith anIC50of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].

IC50& Target

5-HT3Receptor

 

体外研究
(In Vitro)

PNU-282987 (free base) (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Kiof 27 nM[1].
PNU-282987 has α7 nAChR agonist activity with an EC50of 154 nM[1].
PNU-282987 also has inhibition for the 5-HT3receptor with an IC50value of 4541nM[1].

体内研究
(In Vivo)

PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner[1].

Animal Model:Rats[1]
Dosage:1, 3 mg/kg
Administration:i.v.
Result:Significantly reversed amphetamine-induced gating deficit.
分子量

264.75

Formula

C14H17ClN2O

CAS 号

711085-63-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.