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Thioridazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thioridazine图片
CAS NO:50-52-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
硫利达嗪
产品介绍
Thioridazine 是一种具有口服活性的多巴胺受体D2家族蛋白的拮抗剂,具有有效的抗焦虑活性。Thioridazine 也是一种有效的PI3K-Akt-mTOR信号通路的抑制剂,具有抗血管生成作用。Thioridazine 在多种类型的癌细胞中显示出抗增殖和凋亡诱导作用,对靶向癌症干细胞 (CSCs) 具有特异性。
生物活性

Thioridazine, an antagonist of thedopamine receptorD2family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor ofPI3K-Akt-mTORsignaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative andapoptosisinduction effects in various types ofcancercells, with specificity on targetingcancer stem cells(CSCs)[1][2][3][4].

体外研究
(In Vitro)

Thioridazine (0.01-100 μM; 48 h) reduces the cell viability of NCI-N87 and AGS cells in a concentration-dependent manner[2].
Thioridazine (15 μM; 24 h) reduces cell viability of the cervical (HeLa, Caski and C33A) and endometrial (HEC-1-A and KLE) cancer cells[4].
Thioridazine (1-15 μM; 24-48 h) induces gastric cancer cell death via the mitochondrial apoptosis pathway and mitochondrial pathway[2].
Thioridazine (15 μM; 24 h) modulates the regulation of cell cycle progression by interfering with the PI3K/Akt pathway and induces G1cell cycle arrest in cervical and endometrial cancer cells[4].
Thioridazine inhibits the growth of antibiotic-sensitive and multidrug-resistant strains ofA. baumannii[3].

Cell Viability Assay[1]

Cell Line:NCI-N87 and AGS cells.
Concentration:0.01, 0.1, 0.5, 1, 5, 10, 20, 50, 100 μM.
Incubation Time:48 hours.
Result:Exhibited cytotoxicity in gastric cancer cells.

Western Blot Analysis[1]

Cell Line:NCI-N87 and AGS cells
Concentration:1, 5, 10, 15 μM.
Incubation Time:24, 48 hours.
Result:Downregulated the precursors of caspase-9, caspase-8 and caspase-3.
体内研究
(In Vivo)

Thioridazine (25 mg/kg; i.p. every 3 days for 3 weeks) extends the survival of tumor-bearing mice and reduces the number of pluripotent embryonal carcinoma (EC) cells within tumors[5].
Thioridazine (1.0-5.0 mg/kg; s.c.) reduces oral behavior and selectively blocks repetitive head bobbing[1].

Animal Model:Nude and Rag2KO mice were injected with iPS cells or NT2D1 cells[5]
Dosage:25 mg/kg.
Administration:I.p. every 3 days for 3 weeks.
Result:Reduced the number of OCT4-expressing cells within malignant teratocarcinomas and extended the survival of tumor-bearing mice.
With no effect on fertility.
Clinical Trial
分子量

370.57

Formula

C21H26N2S2

CAS 号

50-52-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.