cis-Urocanic acid

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cis-Urocanic acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

7699-35-6

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

顺式-尿刊酸
(Z)-Urocanic acid
cis-UCA

产品介绍

cis-Urocanic acid 是一种5-HT2A受体激动剂。cis-Urocanic acid 以较高亲和力与 5-HT 受体结合，K_d为 4.6 nM。cis-Urocanic acid 是一种免疫调节剂，通过与 5-HT2A 受体结合而诱导免疫抑制。

生物活性

cis-Urocanic acid is a5-HT2A receptoragonist. cis-Urocanic acid binds to5-HT receptorwith relatively high affinity (K_d=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor^[1].

IC₅₀& Target

5-HT_2AReceptor

体外研究
(In Vitro)

Treatment with 100 μg/mL cis-Urocanic acid (cis-UCA) completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types. The 5000 μg/mL concentration is toxic^[1].

Cell Viability Assay^[1]

Cell Line:	Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs)
Concentration:	10, 100, 1,000, and 5,000 μg/mL
Incubation Time:	24, 48, or 72 hours
Result:	Treatment with 100 μg/mL completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells were observed with 100 μg/mL in both cell types.

Clinical Trial

分子量

138.12

性状

Solid

Formula

C₆H₆N₂O₂

CAS 号

7699-35-6

中文名称

顺式-尿刊酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 50 mg/mL(362.00 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	7.2401 mL	36.2004 mL	72.4008 mL
5 mM	1.4480 mL	7.2401 mL	14.4802 mL
10 mM	0.7240 mL	3.6200 mL	7.2401 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。