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BW 755C
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BW 755C图片
CAS NO:66000-40-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Cas No.66000-40-6
化学名4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
Canonical SMILESNC(CC1)=NN1C2=CC=CC(C(F)(F)F)=C2
分子式C10H10F3N3
分子量229.3
溶解度≤30mg/ml in ethanol;30mg/ml in DMSO;25mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 0.75 μM, 0.65 μg/ml, and 1.2 μg/ml for 5-LO, COX-1, and COX-2, respectively

BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.

Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. Since 5-lipoxygenase (5-LO) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid in the first step of the leukotriene pathway, 5-LO inhibitors should prevent leukotriene biosynthesis and thus prove useful in the treatment of allergic asthma.

In vitro: Previous study found that BW 755C and other nonsteroidal antiinflammatory drugs including diclofenac, acetaminophen, and naproxen showed approximately equipotent inhibitory effects on COX-1 and COX-2 in intact cells. Whereas, BF 389 was the most potent and most selective inhibitor of COX-2 in intact cells [1].

In vivo: An animal study was conducted to examine whether BW-755C delayed neuronal death in the hippocampal CA1 sector in Mongolian gerbils after 5 minutes of forebrain ischemia. Gerbils were injected with BW-755C. Seven days after ischemic insult, the animals were perfusion-fixed, and the neuronal density in the hippocampal CA, sector was estimated. Results showed that in ischemic gerbils with vehicle administration, the average neuronal density was 13 for BW-755C. In ischemic gerbils treated with 30 mg/kg BW-755C, the average neuronal densities was 14 [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Mitchell, J. A.,Akarasereenont, P.,Thiemermann, C., et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proceedings of the National Academy of Sciences of the United States of America 90, 11693-11697 (1993).
[2] Nakagomi T, Sasaki T, Kirino T, Tamura A, Noguchi M, Saito I, Takakura K.  Effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus. Stroke. 1989 Jul;20(7):925-9.