CAS NO: | 66000-40-6 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Cas No. | 66000-40-6 |
化学名 | 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine |
Canonical SMILES | NC(CC1)=NN1C2=CC=CC(C(F)(F)F)=C2 |
分子式 | C10H10F3N3 |
分子量 | 229.3 |
溶解度 | ≤30mg/ml in ethanol;30mg/ml in DMSO;25mg/ml in dimethyl formamide |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | IC50: 0.75 μM, 0.65 μg/ml, and 1.2 μg/ml for 5-LO, COX-1, and COX-2, respectively BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. Since 5-lipoxygenase (5-LO) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid in the first step of the leukotriene pathway, 5-LO inhibitors should prevent leukotriene biosynthesis and thus prove useful in the treatment of allergic asthma. In vitro: Previous study found that BW 755C and other nonsteroidal antiinflammatory drugs including diclofenac, acetaminophen, and naproxen showed approximately equipotent inhibitory effects on COX-1 and COX-2 in intact cells. Whereas, BF 389 was the most potent and most selective inhibitor of COX-2 in intact cells [1]. In vivo: An animal study was conducted to examine whether BW-755C delayed neuronal death in the hippocampal CA1 sector in Mongolian gerbils after 5 minutes of forebrain ischemia. Gerbils were injected with BW-755C. Seven days after ischemic insult, the animals were perfusion-fixed, and the neuronal density in the hippocampal CA, sector was estimated. Results showed that in ischemic gerbils with vehicle administration, the average neuronal density was 13 for BW-755C. In ischemic gerbils treated with 30 mg/kg BW-755C, the average neuronal densities was 14 [2]. Clinical trial: So far, no clinical study has been conducted. References: |