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Rhapontigenin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Rhapontigenin图片
CAS NO:500-65-2
包装与价格：
包装价格(元)
5mg电议
10mg电议
20mg电议

产品介绍
Rhapontigenin 是白藜芦醇的天然类似物，具有抗癌、抗氧化、抗真菌和抗菌活性。
Cas No.500-65-2
别名丹叶大黄素
化学名5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol
Canonical SMILESCOc1ccc(/C=C\c2cc(O)cc(O)c2)cc1O
分子式C15H14O4
分子量258.3
溶解度≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rhapontigenin is an apoptosis-inducing agent, and also a potent and selective cytochrome P450 1A1 inhibitor with IC50 value of 0.4 μM [1][2].

Human cytochrome P450 (P450) 1A1 is an aryl hydrocarbon hydroxylase which involved in the metabolic activation of procarcinogens of the polycyclic aromatic hydrocarbons. P450 1A1 is mainly expressed in human lung, placenta, and lymphocytes. Selective inhibitors of P450 1A1 may be good chemopreventive agent candidates for cancer [2].

Rhapontigenin is an apoptosis-inducing agent and a cytochrome P450 1A1 inhibitor. Rhapontigenin inhibited recombinant human cytochrome P450 (P450) 1A1 with IC50 value of 0.4 μM. Rhapontigenin showed 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively. Rhapontigenin showed competitive inhibition of P450 1A1 with Ki value of 0.21 μM [1]. Rhapontigenin is a natural analog of resveratrol, a potential cancer chemopreventive agent. In the HL60 cell line, Rhapontigenin inhibited cell proliferation with IC50 value of 48 μM [2]. In Hep G2 hepatoma cells, Rhapontigenin exhibited concentration-dependent anti-cancer activity with IC50 value of 115 μg/mL [3].

References:
[1].  Chun YJ, Ryu SY, Jeong TC, et al. Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):389-93.
[2].  Roberti M1, Pizzirani D, Simoni D, et al. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. J Med Chem. 2003 Jul 31;46(16):3546-54.
[3].  Roupe KA1, Helms GL, Halls SC, et al. Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies. J Pharm Pharm Sci. 2005 Aug 22;8(3):374-86.