| CAS NO: | 1229-29-4 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Cas No. | 1229-29-4 |
| 别名 | 盐酸多塞平 |
| 化学名 | 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride |
| Canonical SMILES | CN(C)CC/C=C1C2=C(C=CC=C2)COC3=C/1C=CC=C3.Cl |
| 分子式 | C19H21NO o HCl |
| 分子量 | 315.8 |
| 溶解度 | ≥ 15.85mg/mL in DMSO |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein–coupled receptors activated by their primary endogenous ligand histamine. The H1 receptor has been expressed in smooth muscles, vascular endothelial cells, heart, and the central nervous system [2]. In vitro: Doxepin was a moderately potent competitive inhibitor of serotonin uptake in human blood platelets in vitro, with an inhibitory constant Ki of ～0.2 μM. Doxepin (100 μM) rapidly increased the efflux of serotonin from platelets [1]. In vivo: In rats and dog, oral administration of doxepin was well absorbed and quickly appeared in the blood. Numerous metabolites of doxepin were observed in liver and in urine, only doxepin and demethyl doxepin were found in the rat brain[3].. Clinical trials: Doxepin has been marketed under many brand names worldwide. The oral topical formulations of doxepin are FDA-approved for the treatment of patients with major depressive disorder, primary insomnia, chronic urticaria, and anxiety [4,5,6]. References: |
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