CAS NO: | 142477-34-7 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
生物活性 | 5-HT1A modulator 1 displays very high affinities for the5HT1A,adrenergic α1anddopamineD2receptorwithIC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively. | ||||||||||||
IC50& Target |
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体外研究 (In Vitro) | 5-HT1A modulator 1 (Compound 24) also displays affinities for the 5HT1B, 5-HT2Aand 5-HT2Creceptor with IC50s of 300±55 nM, 500±75 nM, and 4000±440 nM, respectively[1]. | ||||||||||||
体内研究 (In Vivo) | 5-HT1A modulator 1 (Compound 24) shows clear antagonist action at 5HT2Areceptor subtype in mice. The antagonism is nearly complete at the dose of 1 mg/kg ip for 5-HT1A modulator 1 (94% of antagonism, p<0.01). 5-HT1A modulator 1 completely blocks the stereotypies and the climbing at the dose of 1 mg/kg ip (100% of antagonism). 5-HT1A modulator 1 is also tested in rats, using the same paradigm. After oral administration, 5-HT1A modulator 1 significantly (p<0.05) reduces the hyperactivity by 50% at the doses of 2 and 4 mg/kg po, respectively 63% and 58% of antagonism for 5-HT1A modulator 1; the antagonism is complete (103% and 108%) at the respective doses of 8 and 16 mg/kg po for 5-HT1A modulator 1 (p<0.01)[1]. | ||||||||||||
分子量 | 383.51 | ||||||||||||
性状 | Solid | ||||||||||||
Formula | C21H25N3O2S | ||||||||||||
CAS 号 | 142477-34-7 | ||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
储存方式 |
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