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5-HT1A modulator 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-HT1A modulator 1图片
CAS NO:142477-34-7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
5-HT1A modulator 1 对5HT1A,肾上腺素能α1和多巴胺D2受体具有非常高的亲和力,IC50分别为 2±0.3 nM,10±3 nM 和 40±9 nM。
生物活性

5-HT1A modulator 1 displays very high affinities for the5HT1A,adrenergic α1anddopamineD2receptorwithIC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively.

IC50& Target

sPLA2

2 nM (IC50)

5-HT2AReceptor

500 nM (IC50)

5-HT2CReceptor

4000 nM (IC50)

α1 receptor

10 nM (IC50)

D2 receptor

40 nM (IC50)

体外研究
(In Vitro)

5-HT1A modulator 1 (Compound 24) also displays affinities for the 5HT1B, 5-HT2Aand 5-HT2Creceptor with IC50s of 300±55 nM, 500±75 nM, and 4000±440 nM, respectively[1].

体内研究
(In Vivo)

5-HT1A modulator 1 (Compound 24) shows clear antagonist action at 5HT2Areceptor subtype in mice. The antagonism is nearly complete at the dose of 1 mg/kg ip for 5-HT1A modulator 1 (94% of antagonism, p<0.01). 5-HT1A modulator 1 completely blocks the stereotypies and the climbing at the dose of 1 mg/kg ip (100% of antagonism). 5-HT1A modulator 1 is also tested in rats, using the same paradigm. After oral administration, 5-HT1A modulator 1 significantly (p<0.05) reduces the hyperactivity by 50% at the doses of 2 and 4 mg/kg po, respectively 63% and 58% of antagonism for 5-HT1A modulator 1; the antagonism is complete (103% and 108%) at the respective doses of 8 and 16 mg/kg po for 5-HT1A modulator 1 (p<0.01)[1].

分子量

383.51

性状

Solid

Formula

C21H25N3O2S

CAS 号

142477-34-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month