BIMU 8 is a potent and selective5-HT4agonist withEC₅₀s of 18 nM, 77 nM, and 540 nM forwild type 5HT4 receptor,T3.36A, andW6.48A mutant 5-HT4 receptors^[1][2].

In myenteric neurons of guinea pig ileum, BIMU 8 (0.003-0.1 μM) increases excitatory postsynaptic potentials (EPSPs) mplitude but does not change the membrane potential of any neuron^[3].

In mice and rats, BIMU 8 (20-30 mg/kg s.c. and 60 mg/kg p.o. in mice; 20 mg/kg i.p. in rats), produces significant antinociception. Intracerebroventricular injection in mice of BIMU 8 (10 μg/mouse), doses which are largely ineffective by parenteral routes, induces an antinociception whose intensity equaled that obtainable s.c., i.p. or p.o^[1].

377.89

Solid

C₁₉H₂₆ClN₄O₂^-

134296-40-5

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)