| CAS NO: | 132812-45-4 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 生物活性 | Blonanserin dihydrochloride is a potent and orally active5-HT2Aanddopamine D2 receptorantagonist, withKivalues of 0.812 and 0.142 nM, respectively. Blonanserin dihydrochloride is usually acts as an atypical antipsychotic agent, and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension[1][2]. | |||||||||
| IC50& Target |
| |||||||||
| 体外研究 (In Vitro) | Blonanserin dihydrochloride exerts some blockade of α1-adrenergic receptors (Ki=26.7 nM) and also shows significant affinity for the D3 receptor (Ki=0.494 nM). Blonanserin dihydrochloride possesses low affinity for the sigma receptor (IC50=286 nM), but lacks significant affinity for numerous other sites including the 5-HT1A, 5-HT3, D1, α2-adrenergic, β-adrenergic, H1, and mACh receptors and the monoamine transporters[1]. | |||||||||
| 体内研究 (In Vivo) | Blonanserin dihydrochloride (Oral gavage; 1 mg/kg; once a day for 14 days) significantly ameliorates the social deficit observed in PCP-administered mice and inhibits the decrease in the levels of Ser897-phosphorylation, but preatment with blonanserin does not affect the social behaviors in saline-administered mice[2].
| |||||||||
| Clinical Trial | ||||||||||
| 分子量 | 440.42 | |||||||||
| Formula | C23H32Cl2FN3 | |||||||||
| CAS 号 | 132812-45-4 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
m.cnreagent.com