CAS NO: | 209481-20-9 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | SB 271046 is a potent, selective and orally active5-HT6 receptorantagonist with apKiof 8.92-9.09. SB 271046 show >200-fold selective for the 5-HT6 receptor over other receptors, binding sites and ion channels. SB 271046 has anticonvulsant activity[1]. | |
IC50& Target[1] |
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体外研究 (In Vitro) | In functional studies on human 5-HT6 receptors SB 271046 competitively antagonized 5-HT-induced stimulation of adenylyl cyclase activity with a pA2of 8.71[1]. | |
体内研究 (In Vivo) | SB 271046 produces an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of ?0.1 mg/kg p.o. and maximum effect at 4 h post-dose. The level of anticonvulsant activity achieved correlated well with the blood concentrations of SB 271046 (EC50of 0.16 μM) and brain concentrations of 0.01-0.04 μM at Cmax[1]. | |
分子量 | 451.99 | |
Formula | C20H22ClN3O3S2 | |
CAS 号 | 209481-20-9 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |