CAS NO: | 874882-92-5 |
包装: | 5mg |
生物活性 | Isamoltane hemifumarate is a selective antagonist of5-HT1Breceptor, with anIC50of 39 nM for inhibits the binding of [125I]ICYP to 5-HT1Brecognition sites in rat brain membranes. Isamoltane hemifumarate is also aβ-adrenoceptorligand, with anIC50of 8.4 nM. Isamoltane hemifumarate shows anxiolytic activity[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Isamoltane exhibits 27-fold selectivity for the 5-HT1Breceptor over 5-HT1A(IC50=1070 nM) in rat brain membranes[1]. | ||||||||
体内研究 (In Vivo) | Isamoltane (0.3-30 mg/kg; i.p) does not alter the accumulation of 5-HTP in the rat hippocampus, and increases 5-HT synthesis in cortical tissue. Isamoltane reduces 5-HTP accumulation in the striatum[1].
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分子量 | 332.40 | ||||||||
Formula | C16H22N2O2.1/2C4H4O4 | ||||||||
CAS 号 | 874882-92-5 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |