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WAY-181187 oxalate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WAY-181187 oxalate图片
CAS NO:1883548-85-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
SAX-187 oxalate
产品介绍
WAY-181187 (SAX-187) oxalate 是一种有效的选择性5-HT6受体激动剂,Ki为 2.2 nM,EC50为 6.6 nM。WAY-181187 oxalate 介导 5-HT6 受体依赖性信号通路,如 cAMP,Fyn 和 ERK1/2 激酶,作为特异性激动剂。
生物活性

WAY-181187 (SAX-187) oxalate is a potent and selective full5-HT6receptor agonist with aKiof 2.2 nM and anEC50of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[1][2].

IC50& Target

5-HT6Receptor

2.2 nM (Ki)

5-HT6Receptor

6.6 nM (EC50)

体外研究
(In Vitro)

WAY-181187 (SAX-187) oxalate (1 and 10 μM) increases activation of ERK1/2. WAY181187 also increases Fyn kinase activity[2].

体内研究
(In Vivo)

Acute administration of WAY-181187 (SAX-187) oxalate (3-30 mg/kg, s.c.) significantly increases extracellular GABA concentrations without altering the levels of glutamate or norepinephrine in the rat frontal cortex. Additionally, WAY-181187 oxalate (30 mg/kg, s.c.) produces modest yet significant decreases in cortical dopamine and 5-HT levels[1].

分子量

470.91

Formula

C17H15ClN4O6S2

CAS 号

1883548-85-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.