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BRL-15572 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BRL-15572 hydrochloride图片
CAS NO:1173022-77-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
BRL-15572 hydrochloride 是h5-HT1D的选择性拮抗剂,对h5-HT1D受体显示出高亲和力。 BRL-15572 hydrochloride 可能是表征h5-HT1D受体介导的反应的有用药理剂。
生物活性

BRL-15572 hydrochloride is a selective antagonist ofh5-HT1D, displays high affinity forh5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise5-HT1D receptormediated responses[1].

IC50& Target[1]

5-HT1DReceptor

 

体外研究
(In Vitro)

BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells[1].
BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors[1].

体内研究
(In Vivo)

BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3].

分子量

443.41

Formula

C25H28Cl2N2O

CAS 号

1173022-77-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.