CAS NO: | 57226-68-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride bycytochrome P450(CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits5-HTuptake and inhibitsCaV3.3 Tcurrent (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity[1][2][3][4]. | ||
IC50& Target[1] |
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体内研究 (In Vivo) | Pretreatment with Fluoxetine or Norfluoxetine hydrochloride (20mg/kg s.c.), as well as Phenytoin (30 mg/kg s.c.) and Clonazepam (0.1mg/kg s.c.) significantly increases both the rate and duration of survival, demonstrating a significant protective effect against Pentylenetetrazol-induced epilepsy[1]. | ||
分子量 | 331.76 | ||
Formula | C16H17ClF3NO | ||
CAS 号 | 57226-68-3 | ||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |