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Norfluoxetine Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Norfluoxetine Hydrochloride图片
CAS NO:57226-68-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Norfluoxetine hydrochloride 是 Fluoxetine 的 N-去甲基化活性代谢物。Fluoxetine 是一种选择性血清素 (5-HT) 再摄取抑制剂,可通过细胞色素 P450 (CYP) 2D6、CYP2C19 和 CYP3A4 代谢为 Norfluoxetine hydrochloride。Norfluoxetine hydrochloride 抑制5-HT摄取并抑制CaV3.3 T电流 (IC50=5 μM)。Norfluoxetine hydrochloride 具有抗惊厥活性。
生物活性

Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride bycytochrome P450(CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits5-HTuptake and inhibitsCaV3.3 Tcurrent (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity[1][2][3][4].

IC50& Target[1]

5-HT Receptor

 

CaV3.3

5 μM (IC50)

体内研究
(In Vivo)

Pretreatment with Fluoxetine or Norfluoxetine hydrochloride (20mg/kg s.c.), as well as Phenytoin (30 mg/kg s.c.) and Clonazepam (0.1mg/kg s.c.) significantly increases both the rate and duration of survival, demonstrating a significant protective effect against Pentylenetetrazol-induced epilepsy[1].

分子量

331.76

Formula

C16H17ClF3NO

CAS 号

57226-68-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.