Org-12962 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

210821-63-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Org 12962 hydrochloride 是一种有效的、选择性的 5-HT_2C受体激动剂，对 5-HT_2C，5-HT_2A，5-HT_2B的pEC₅₀分别为 7.01、6.38 和 6.28。Org 12962 hydrochloride 在焦虑大鼠的模型中显示出缓解作用。

生物活性

Org 12962 hydrochloride is a potent, selective and efficacious 5-HT_2C receptor agonist and exhibitspEC₅₀ values of 7.01, 6.38 and 6.28 for 5-HT_2C, 5-HT_2A and 5-HT_2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model^[2].

IC₅₀& Target^[1]^[2]

5-HT_2CReceptor

7.01 (pEC₅₀)

5-HT_2AReceptor

6.38 (pEC₅₀)

5-HT_2BReceptor

6.28 (pEC₅₀)

体内研究
(In Vivo)

Org 12962 (intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F_3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects^[3].

Animal Model:	Male Wistar rats^[3]
Dosage:	0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Administration:	Intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Result:	Had a dose-related antipanic-like effect in SD-rat.

分子量

302.12

Formula

C₁₀H₁₂Cl₂F₃N₃

CAS 号

210821-63-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.