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SB-221284
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB-221284图片
CAS NO:196965-14-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
SB 221284 是一种选择性5-HT2C/2B受体拮抗剂,5-HT2A,5-HT2B5-HT2C受体的pKi值分别为 6.4, 7.9 和 8.6。SB 221284可用于神经系统疾病的研究.
生物活性

SB 221284 is a selective5-HT2C/2Breceptor antagonist withpKivalues are 6.4, 7.9 and 8.6 for5-HT2A,5-HT2Band5-HT2Creceptors, respectively. SB 221284 can be used for the research ofneurological disease[1].

IC50& Target[1]

5-HT2AReceptor

6.4 (pKi)

5-HT2BReceptor

7.9 (pKi)

5-HT2CReceptor

8.6 (pKi)

体内研究
(In Vivo)

SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1].
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1]

Animal Model:Male Sprague Dawley rats (250–360 g)[1]
Dosage:0.1~1 mg/kg
Administration:I.p.
Result:Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.
Animal Model:Male Sprague Dawley rats (250–360 g)[1]
Dosage:1 mg/kg
Administration:I.p.
Result:Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.
分子量

353.36

Formula

C16H14F3N3OS

CAS 号

196965-14-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.