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U92016A hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
U92016A hydrochloride图片
CAS NO:149654-41-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
U92016A hydrochloride 是一种代谢稳定、具有口服活性的5-HT1A受体激动剂,具有极高的内在活性。U92016A hydrochloride 以高亲和力与中国仓鼠卵巢细胞中表达的人 5-HT1A 受体结合 (Ki=0.2 nM)。
生物活性

U92016A hydrochloride is a potent, metabolically stable, orally acitive5-HT1Areceptor agonist with an exceptionally high degree of intrinsic activity[1][2]. U92016A hydrochloride binds with high affinity to human 5-HT1A receptors expressed in Chinese hamster ovary cells (Ki=0.2 nM)[2].

IC50& Target[2]

5-HT1AReceptor

0.2 nM (Ki)

体外研究
(In Vitro)

U92016A (U-92016A) is selective for the 5-HT1A receptor over other biogenic amine receptors. U92016A decreases the Forskolin-induced increase in cyclic AMP synthesis and has an intrinsic activity of 0.82 relative to 5-HT in Chinese hamster ovary cells expressing the human 5HT1A receptor[2].

体内研究
(In Vivo)

U92016A (U-92016A) potently decreases rectal temperature in mice. U92016A also elicits the 5-HT-mediated syndrome in rats and results in a dose-related decrease in 5-hydroxytryptophan accumulation. U92016A also decreases arterial blood pressure in spontaneously hypertensive rats and inhibits sympathetic nerve activity in cats. U92016A displays excellent potency and a long duration of action. U92016A also inhibits the firing of dorsal raphe 5-HT neurons and is active in two social interaction assays. The p.o. bioavailability of U92016A is 45%[2].

分子量

331.88

Formula

C19H26ClN3

CAS 号

149654-41-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.