CAS NO: | 105565-55-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally activesigma receptorantagonist with anIC50of 112 nM. BMY-14802 hydrochloride is also a5-HT1Aandadrenergic α1 receptorsagonist. BMY-14802 hydrochloride has antipsychotic effects[1][2][3]. | |||
IC50& Target[1] |
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体外研究 (In Vitro) | Similar to other 5-HT1A agonists, BMY-14802 hydrochloride affects the firing of 5-HTergic and catecholaminergic neurons and affects behaviors mediated by 5-HT in a 5-HT1A-sensitive manner. BMY-14802 hydrochloride is devoid of significant affinity for the D2 receptor[3]. | |||
体内研究 (In Vivo) | BMY-14802 (5 mg/kg, 10 mg/kg or 20 mg/kg, ip; once) hydrochloride shows anti-dyskinetic efficacy across a 4-fold dose range against L-DOPA-induced dyskinesias (LID) and is also effective in reducing D1 and D2 receptor agonist-induced dyskinesias. Importantly, at anti-LID doses, BMY-14802 hydrochloride does not affect the efficacy of L-DOPA against lesion-induced akinesia[2]. | |||
分子量 | 384.85 | |||
Formula | C18H23ClF2N4O | |||
CAS 号 | 105565-55-7 | |||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |