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BMY-14802 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMY-14802 hydrochloride图片
CAS NO:105565-55-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
BMY-14802-1
BMS 181100 hydrochloride
产品介绍
BMY-14802 hydrochloride (BMY-14802-1) 是一种选择性和具有口服活性的 σ 受体 (sigma receptor) 拮抗剂,IC50为 112 nM。BMY-14802 hydrochloride 也是一种5-HT1A和肾上腺素α1受体激动剂。BMY-14802 hydrochloride 具有抗精神病作用。
生物活性

BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally activesigma receptorantagonist with anIC50of 112 nM. BMY-14802 hydrochloride is also a5-HT1Aandadrenergic α1 receptorsagonist. BMY-14802 hydrochloride has antipsychotic effects[1][2][3].

IC50& Target[1]

5-HT1AReceptor

 

α1-adrenergic receptor

 

sigma Receptor

112 nM (IC50)

体外研究
(In Vitro)

Similar to other 5-HT1A agonists, BMY-14802 hydrochloride affects the firing of 5-HTergic and catecholaminergic neurons and affects behaviors mediated by 5-HT in a 5-HT1A-sensitive manner. BMY-14802 hydrochloride is devoid of significant affinity for the D2 receptor[3].

体内研究
(In Vivo)

BMY-14802 (5 mg/kg, 10 mg/kg or 20 mg/kg, ip; once) hydrochloride shows anti-dyskinetic efficacy across a 4-fold dose range against L-DOPA-induced dyskinesias (LID) and is also effective in reducing D1 and D2 receptor agonist-induced dyskinesias. Importantly, at anti-LID doses, BMY-14802 hydrochloride does not affect the efficacy of L-DOPA against lesion-induced akinesia[2].

分子量

384.85

Formula

C18H23ClF2N4O

CAS 号

105565-55-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.