LP 12 hydrochloride (compound 21) is a potent and selective5-HT7 receptoragonist with aK_iof 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (K_ivalues are 224 nM, 60.9 nM and >1000 nM, respectively)^[1][2].

LP 12 hydrochloride (0.13 nM; spermatozoa) increases the percentage of hyperactivated spermatozoa. LP 12 hydrochloride do not affect straight-line velocity (VSL), curvilinear velocity (VCL), average-path velocity (VAP), linearity (LIN), straightness (STR), wobbler coefficient (WOB), amplitude of lateral head displacement (ALH), and beat-cross frequency (BCF)^[2].

518.13

C₃₂H₄₀ClN₃O

1185136-22-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.