Eletriptan

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Eletriptan

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

143322-58-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

UK-116044

产品介绍

Eletriptan (UK-116044) 是一种高选择性且具有口服活性的5-HT_1B和5-HT_1D受体激动剂，pK_i分别为 8.0 和 8.9。Eletriptan 对大鼠神经源性炎症标志物有抑制作用。Eletriptan 可用于偏头痛的研究。

生物活性

Eletriptan (UK-116044) is a highly selective and orally active serotonin5-HT_1Band5-HT_1Dreceptor agonist, withpK_ivalues of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine^[1].

IC₅₀& Target^[1]

5-HT_1BReceptor

8.0 (pKi)

5-HT_1DReceptor

8.9 (pKi)

体内研究
(In Vivo)

Eletriptan (10, 30, 100, 300 and 1000 μg/kg; i.v.) reduces total carotid blood flow in anaesthetised pigs by selectively reducing carotid arteriovenous anastomotic blood flow and increasing nutrient blood flow within the carotid vascular bed^[2].

Clinical Trial

分子量

382.52

Formula

C₂₂H₂₆N₂O₂S

CAS 号

143322-58-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.