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Iloperidone hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Iloperidone hydrochloride图片
CAS NO:1299470-39-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
盐酸伊潘立酮
HP 873 hydrochloride
产品介绍
Iloperidone hydrochloride (HP 873 hydrochloride) 是一种D2/5-HT2受体拮抗剂,可作用于精神分裂症的非典型抗精神病药。
生物活性

Iloperidone hydrochloride (HP 873 hydrochloride) is aD2/5-HT2receptor antagonist. Iloperidone hydrochloride is an atypical antipsychotic for the schizophrenia symptoms[1][2].

IC50& Target[1]

Rat D2Receptor

54 nM (Ki)

Rat 5-HT2Receptor

3.1 nM (Ki)

Rat D1Receptor

546 nM (Ki)

Rat 5-HT1AReceptor

168 nM (Ki)

Rat 5-HT6Receptor

42.7 nM (Ki)

Rat 5-HT7Receptor

21.6 nM (Ki)

Human D1Receptor

216 nM (Ki)

Human D3Receptor

7.1 nM (Ki)

Human D4Receptor

25 nM (Ki)

Human D5Receptor

319 nM (Ki)

Human 5-HT2AReceptor

5.6 nM (Ki)

Human 5-HT2CReceptor

42.8 nM (Ki)

体外研究
(In Vitro)

Iloperidone hydrochloride displays higher affinity for the dopamine D3receptor (Ki=7.1 nM) than for the dopamine D4receptor (Ki=25 nM). Iloperidone displays high affinity for the 5-HT6and 5-HT7receptors (Ki=42.7 and 21.6 nM, respectively), and is found to have higher affinity for the 5-HT2A(Ki=5.6 nM) than for the 5-HT2Creceptor (Ki=42.8 nM)[1].

体内研究
(In Vivo)

Iloperidone hydrochloride is eliminated slowly, with a mean t1/2of 13.5 to 14.0 hours. Coadministration with food did not significantly affect AUC, tmax, or Cmax. These results indicate that the rate of iloperidone's absorption is decreased, but the overall bioavailability is unchanged, when the drug is taken with food. Orthostatic hypotension, dizziness, and somnolence were the most commonly reported adverse events[2].

Clinical Trial
分子量

462.94

Formula

C24H28ClFN2O4

CAS 号

1299470-39-5

中文名称

盐酸伊潘立酮;盐酸哌啶酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.