CAS NO: | 1299470-39-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Iloperidone hydrochloride (HP 873 hydrochloride) is aD2/5-HT2receptor antagonist. Iloperidone hydrochloride is an atypical antipsychotic for the schizophrenia symptoms[1][2]. | ||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Iloperidone hydrochloride displays higher affinity for the dopamine D3receptor (Ki=7.1 nM) than for the dopamine D4receptor (Ki=25 nM). Iloperidone displays high affinity for the 5-HT6and 5-HT7receptors (Ki=42.7 and 21.6 nM, respectively), and is found to have higher affinity for the 5-HT2A(Ki=5.6 nM) than for the 5-HT2Creceptor (Ki=42.8 nM)[1]. | ||||||||||||
体内研究 (In Vivo) | Iloperidone hydrochloride is eliminated slowly, with a mean t1/2of 13.5 to 14.0 hours. Coadministration with food did not significantly affect AUC, tmax, or Cmax. These results indicate that the rate of iloperidone's absorption is decreased, but the overall bioavailability is unchanged, when the drug is taken with food. Orthostatic hypotension, dizziness, and somnolence were the most commonly reported adverse events[2]. | ||||||||||||
Clinical Trial | |||||||||||||
分子量 | 462.94 | ||||||||||||
Formula | C24H28ClFN2O4 | ||||||||||||
CAS 号 | 1299470-39-5 | ||||||||||||
中文名称 | 盐酸伊潘立酮;盐酸哌啶酮 | ||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |