您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Alosetron(Hydrochloride(1:X))
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Alosetron(Hydrochloride(1:X))
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alosetron(Hydrochloride(1:X))图片
CAS NO:132414-02-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
GR 68755 (Hydrochloride(1:X))
GR 68755X (Hydrochloride(1:X))
产品介绍
Alosetron (GR 68755) Hydrochloride(1:X) 是一种高效、高选择性的 5-HT3 受体 (5-HT3 receptor) 拮抗剂。Alosetron Hydrochloride(1:X) 用于肠易激综合征 (IBS) 的研究。Alosetron Hydrochloride(1:X) 阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化,IC50在 ~55 nM。Alosetron Hydrochloride(1:X) 减轻清醒或麻醉犬直肠扩张的内脏伤害性效应。具有抗炎活性。
生物活性

Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin5-HT3 receptorantagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2].

IC50& Target

5-HT3Receptor

 

体内研究
(In Vivo)

Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis[2].

Clinical Trial
Formula

C17H18N4O.xHCl

CAS 号

132414-02-9

中文名称

阿洛司琼 (盐酸 (1:X))

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.