AR-A 2 is a selective5-HT_1Breceptorantagonist, with high affinity to guinea pig cortex5HT_1B/1Dand recombinant guinea pig5-HT_1Breceptors(K_i=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig5-HT_1Dreceptor(K_i, 5 nM), and shows anEC₅₀of 4.5 nM for the guinea pig5-HT_1Breceptor; AR-A 2 can be used in the research of depression and anxiety.

AR-A 2 (AR-A000002) is a selective 5-HT_1Breceptor antagonist, with high affinity to guinea pig cortex 5HT_1B/1Dand recombinant guinea pig 5-HT_1Breceptors (K_i=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT_1Dreceptors (K_i, 5 nM), and shows an EC₅₀of 4.5 nM for the guinea pig 5-HT_1Breceptor. AR-A 2 also binds to the rat cortical 5HT_1B/1Dreceptor (K_i, 20 nM), rat cortex 5-HT_2Areceptor (K_i, 339 nM), rat hippocampus 5-HT_1Areceptor (K_i, 3070 nM). In addition, AR-A 2 also exhibits affinity for dopamine D2 (K_i, 330 nM) and α1-adrenoceptors (K_i, 490 nM)^[1].

448.60

C₂₇H₃₆N₄O₂

220051-79-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.