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Angiopeptin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Angiopeptin图片
CAS NO:113294-82-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
血管抑肽
产品介绍
Angiopeptin 是生长抑素的环状八肽类似物,是一种sst2/sst5受体部分激动剂,IC50值分别为 0.26 nM 和 6.92 nM。Angiopeptin 可以抑制生长激素释放和胰岛素样生长因子-1 (IGF-1) 产生。Angiopeptin 抑制腺苷酸环化酶或刺激细胞外酸化。Angiopeptin 具有用于冠状动脉粥样硬化研究的潜力。
生物活性

Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weaksst2/sst5receptor partial agonist withIC50values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release andinsulin-like growth factor-1 (IGF-1)production. Angiopeptin inhibitsadenylate cyclaseor stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research[1][2].

IC50& Target

IC50: 0.26 nM (sst2) and 6.92 nM (sst5)[1][2]

体外研究
(In Vitro)

Angiopeptin (0.1 nM- 10 μM; for 1 h) acts as a partial agonist (pEC50=6.57) with a maximum response of 423% at 3 μM on the release of tritium on CHO hsst2cells[2].

体内研究
(In Vivo)

Angiopeptin (20 and 50μg/kg; i.h.) significantly inhibits neointimal formation[1].
Angiopeptin (20 μg/kg; per day) significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%[1].

分子量

1098.34

Formula

C54H71N11O10S2

CAS 号

113294-82-9

Sequence Shortening

{Nal}CYWKVCT-NH2

中文名称

血管抑肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.