Angiotensin III,human,mouse

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CAS NO:

13602-53-4

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

Angiotensin III, human, mouse 是一种七肽，为血管紧张素 2 型受体 (AT₂R) 激动剂，对 AT₂R 和 AT₁R 的IC₅₀值分别为 0.648 nM 和 21.1 nM。

生物活性

Angiotensin III, human, mouse is a heptapeptide, acts as an endogenousangiotensin type 2 receptor (AT₂R)agonist, withIC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively.

IC₅₀& Target

IC50: 0.648 nM (AT₂R), 21.1 nM (AT₁R)^[1]

体外研究
(In Vitro)

Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively^[1].

体内研究
(In Vivo)

Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (U_NaV), fractional excretion of sodium (FE_Na), and fractional excretion of lithium (FE_Li) in SD rat^[2]. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats^[3].

分子量

931.09

性状

Solid

Formula

C₄₆H₆₆N₁₂O₉

CAS 号

13602-53-4

Sequence

Arg-Val-Tyr-Ile-His-Pro-Phe

Sequence Shortening

RVYIHPF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 100 mg/mL(107.40 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.0740 mL	5.3700 mL	10.7401 mL
5 mM	0.2148 mL	1.0740 mL	2.1480 mL
10 mM	0.1074 mL	0.5370 mL	1.0740 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。