Lobradimil

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Lobradimil

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

159768-75-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

RMP 7

产品介绍

Lobradimil (RMP 7) 是一种合成形式的的缓激肽 (bradykinin) 类似物，是一种有效的选择性缓激肽 B2 受体 (bradykinin B2 receptor) 激动剂 (K_i: 0.54 nM)。Lobradimil 可增加 BBB 的渗透性。Lobradimil 可用于脑肿瘤的研究。

生物活性

Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selectivebradykinin B2 receptoragonist (K_i: 0.54 nM). Lobradimil increases the permeability of the BBB. Lobradimil can be used in the research of brain tumors^[1].

IC₅₀& Target^[1]

Bradykinin B2 Receptor (B2R)

0.54 nM (Ki)

体外研究
(In Vitro)

Lobradimil induces an increase in intracellular free calcium levels in RBME cells^[3].
Lobradimil (0.01-0.5 nM, 15 min) increases the permeability of human brain microvascular endothelial cell (HMBEC) monolayers1^[4].

体内研究
(In Vivo)

Lobradimil (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) increases brain tumor permeability and shows hypotensive effects in RG2 glioma cells-implanted rats^[2].

Animal Model:	RG2 glioma cells-implanted rats^[2]
Dosage:	1.5-18 μg/kg
Administration:	i.v. infusion, 0.05 mL/min for 15min
Result:	IncreasedCarboplatin(HY-17393) uptake (up to 80%) into brain tumors in a dose-dependent manner.

Clinical Trial

分子量

1098.28

Formula

C₄₉H₇₅N₁₅O₁₂S

CAS 号

159768-75-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.