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NE 100 hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NE 100 hydrochloride图片
CAS NO:149409-57-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
NE-100 (hydrochloride) 是一种有效的选择性 sigma-1 受体拮抗剂，IC50 为 4.16 nM。
Cas No.149409-57-4
别名N,N-二乙基-2-(4-甲氧基-3-苯乙基氧基苯基)乙胺盐酸盐
化学名N-(4-methoxy-3-phenethoxyphenethyl)-N-propylpropan-1-amine hydrochloride
Canonical SMILESCCCN(CCC1=CC(OCCC2=CC=CC=C2)=C(OC)C=C1)CCC.Cl
分子式C23H33NO2.HCl
分子量391.97
溶解度DMF: 30 mg/mL,DMSO: 30 mg/mL,Ethanol: 30 mg/mL,PBS (pH 7.2): 0.25 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NE 100 is a potent antagonist of sigma-1 (σ1) receptors (IC50 = 4.16 nM).[1],[2],[3] It only weakly antagonizes dopamine, serotonin, and PCP receptors, but may indirectly alter receptor activity through its effects on σ1.[1],[2],[3] NE 100 is commonly used to study the role of σ1 receptor signaling in cells or animals.[4],[5]

Reference:
[1]. Chaki, S., Tanaka, M., Muramatsu, M., et al. NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain. Eur. J. Pharmacol. 251(1), R1-2 (1994).
[2]. Okuyama, S., Imagawa, Y., Ogawa, S., et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 53(18), PL285-PL290 (1993).
[3]. Yamamoto, H., Yamamoto, T., Sagi, N., et al. NE-100, a novel sigma ligand: Effects on [3H]TCP binding to intact primary cultured neuronal cells. Life Sci. 56(2), PL39-PL43 (1995).
[4]. Dalwadi, D.A., Kim, S., and Schetz, J.A. Activation of the sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astroglia. Neurochem Int. 105(5), 27-31 (2017).
[5]. Hong, J., Sha, S., Zhou, L., et al. Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons. Cell Death Dis. 6, e1832 (2015).