| CAS NO: | 104075-48-1 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 10mg | 电议 |
| Cas No. | 104075-48-1 |
| 别名 | 阿替美唑盐酸盐; MPV-1248 hydrochloride |
| 化学名 | 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride |
| Canonical SMILES | CCC1(C2=CN=CN2)CC3=CC=CC=C3C1.Cl |
| 分子式 | C14H16N2.HCl |
| 分子量 | 248.75 |
| 溶解度 | ≥ 24.9mg/mL in EtOH with ultrasonic |
| 储存条件 | Desiccate at 4°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM. The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1]. Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory[1]. References: |
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