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KT109
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KT109图片
CAS NO:1402612-55-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
KT109 是一种有效的异构体选择性二酰基甘油脂肪酶-β (DAGLβ) 抑制剂,IC50 为 42 nM。
Cas No.1402612-55-8
Canonical SMILESO=C(N1N=NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)N4C(CC5=CC=CC=C5)CCCC4
分子式C27H26N4O
分子量422.5
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. KT109 is a selective inhibitor of DAGLβ with an IC50 value of 42 nM. It demonstrates ~60-fold selectivity for DAGLβ over DAGLα, and negligible activity against other key enzymes involved in endocannabinoid signaling, including FAAH, MAGL, and ABHD11. KT109 has been shown to disrupt the lipid network involved in macrophage inflammatory responses, lowering 2-AG, as well as arachidonic acid and eicosanoids, in mouse peritoneal macrophages.