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CB2 receptor agonist 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CB2 receptor agonist 2图片
CAS NO:1314230-75-5
包装:1mg
市场价:2200元

产品介绍
CB2 receptor agonist 2 是CB2受体的有效和选择性激动剂。对CB2Ki为 8.5 nM。CB2 receptor agonist 2 对CB2具有高亲和力和选择性。
生物活性

CB2receptor agonist 2 is a potent and selective agonist for theCB2(cannabinoid type 2) receptor with aKiof 8.5 nM.CB2receptor agonist 2 has high affinity and selectivity forCB2[1].

IC50& Target[1]

CB2

8.5 nM (Ki)

体外研究
(In Vitro)

CB2 receptor agonist 2 (compound 4g) (1 μM; 72 hours) has very low or no cytotoxicity to Hep-G2 cells[1].

Cell Proliferation Assay[1]

Cell Line:Hep-G2 (Human hepatoblastoma) cells
Concentration:1 μM
Incubation Time:72 hours
Result:Exhibited very low or no cytotoxicity to Hep-G2 cells.
体内研究
(In Vivo)

CB2 receptor agonist 2 (compound 4g) (1 and 3 mg/kg; 1 hour) is very potent (with maximal effect being reached already at the 1 mg/kg dose) and has antihyperalgesic effects, efficacious also on the first phase of the nocifensive response and strongly reduced by AM630 (CB2-selective antagonist/inverse agonist)[1].

Animal Model:Formalin injection induces a biphasic stereotypical nocifensive behavior in mice[1]
Dosage:Formalin (1.25% in saline, 30 μL), 1 and 3 mg/kg CB2 receptor agonist 2, 1 mg/kg AM630, monitor every 5 minutes for 1 hour
Administration:Injection in the dorsal surface of one side of the hindpaw (Formalin), i.p. (CB2 receptor agonist, AM630)
Result:Elicited antihyperalgesic effects and potent (with maximal effect being reached already at the 1 mg/kg dose) and efficacious, strongly reduced by AM630.
分子量

488.62

Formula

C30H36N2O4

CAS 号

1314230-75-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.