CBR Agonist-1

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CBR Agonist-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CBR Agonist-1 (27a-cis) 是大麻素受体 (CBR) 激动剂，作用于 CB₁R 和 CB₂R 的K_i值分别是 0.18 μM 和 1.22 μM。CBR Agonist-1 (27a-cis) 可用于内源性大麻素系统相关疾病的研究。

生物活性

CBR Agonist-1 (27a-cis) is acannabinoid receptor(CBR) agonist with theK_ivalues of 0.18 μM for CB₁R and 1.22 μM for CB₂R. CBR Agonist-1 (27a-cis) can be used in the study of endogenous cannabinoid system-related diseases^[1].

IC₅₀& Target^[1]

rCB1-R

0.18 μM (Ki)

hCB2-R

1.22 μM (Ki)

体外研究
(In Vitro)

CBR Agonist-1 (27a-cis) (24 h) can activate GRABeCB2.0 (fluorescent CB₁R sensor) in a concentration-dependent manner with the EC₅₀value of 2.1 μM in HEK293T cell lines^[1].
CBR Agonist-1 (27a-cis) (0-10 mM) acts on hCB₁R calcium mobilization with the IC₅₀value of 3.10 μM in overexpressed hCB₁R CHO-K₁cells^[1].
CBR Agonist-1 (27a-cis) (10-1000 nM, 15 min) induces increased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in a dose-dependent manner in expressed Gαq16 and hCB₁CHO cells^[1].

分子量

442.53

Formula

C₂₇H₂₇FN₄O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.