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Divalproex Sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Divalproex Sodium图片
CAS NO:76584-70-8
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)310.41
FormulaC8H16O2.C8H15O2.Na
CAS No.76584-70-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 62 mg/mL (199.7 mM)
Water: 62 mg/mL (199.7 mM)
Ethanol: 62 mg/mL (199.7 mM)
SMILESCCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]
SynonymsValproate semisodium
实验参考方法
In Vitro

In vitro activity: Divalproex sodium enhances IM-induced cell growth inhibition, apoptosis and cell cycle arrest in K562-S and K562-G cells. Divalproex sodium enhances the inhibitory effects of IM on SIRT1 expression in K562-S and K562-G cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1. Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas a lower dose of Divalproex, 50 mg/kg, has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC.

In Vivo
Animal model
Formulation & Dosage
References

Cancer Lett. 2015 Jan 28;356(2 Pt B):791-9.