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LY288513
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY288513图片
CAS NO:147523-65-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LY288513,一种选择性非肽CCK-B受体拮抗剂,其 IC50值为 16 nM。LY288513 在小鼠体内产生抗焦虑作用。
生物活性

LY288513 is a selective non-peptideCCK-Breceptor antagonist with an IC50value of 16 nM. LY288513 produces an anxiolytic-like action in mice[1][2][3].

IC50& Target

IC50: 16 nM (CCK-B receptor)[1]

体外研究
(In Vitro)

LY288513 (10 nM; 2 days) suppresses the effects of CCK-8 on CD4+T cell subset-specific transcription factors[2].

RT-PCR[2]

Cell Line:CD4+T cells
Concentration:10 nM
Incubation Time:2 days
Result:Suppressed the effects of CCK-8 on CD4+T cell subset-specific transcription factors.
体内研究
(In Vivo)

LY288513 (3, 10 mg/kg, i.p.; 10, 30 mg/kg, p.o.) produces an anxiolytic-like action in mice[3].
LY288513 (1000 mg/kg, p.o.) potentiates the effects of a CNS depressant, slightly lowered body temperature, and had modest sedative effects only at the highest dose examined[3].

Animal Model:Male CD-l mice[3]
Dosage:3, 10 mg/kg; 10, 30 mg/kg
Administration:I.p.; p.o.
Result:Displayed anxiolytic-like effects in the elevated plusmaze.
分子量

436.30

Formula

C22H18BrN3O2

CAS 号

147523-65-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.