CAS NO: | 118101-09-0 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | L-365260 is an orally active and selective antagonist of non-peptidegastrinandbraincholecystokinin receptor(CCK-B), withKis of 1.9 nM and 2.0 nM, respectively. L-365260 interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brainCCK receptors. L-365260 can enhance Morphine analgesia and prevents Morphine tolerance[1][2][3]. | ||||||||||||
IC50& Target |
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体外研究 (In Vitro) | L-365260 (1 μM) strongly attenuates the CCK8S- and CCK4-mediated depolarization in a different neuron[2]. | ||||||||||||
体内研究 (In Vivo) | L-365260 (0.01-10 mg/kg; s.c.) enhances analgesia induced by a submaximal dose of Morphine (4 mg/kg) in rats[3].
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分子量 | 398.46 | ||||||||||||
性状 | Solid | ||||||||||||
Formula | C24H22N4O2 | ||||||||||||
CAS 号 | 118101-09-0 | ||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
储存方式 |
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