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[DPro5] Corticotropin Releasing Factor,human,rat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:195628-97-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
[DPro5] Corticotropin Releasing Factor, human, rat 是促肾上腺皮质激素释放因子/激素 R2 的选择性激动剂。促肾上腺皮质激素释放因子 (CRF) 是一种下丘脑激素,能刺激肾上腺皮质激素 (ACTH) 和 β-内啡肽的分泌。[DPro5] Corticotropin Releasing Factor, human, rat 不引起典型的焦虑效应,但能够调节大鼠的学习和记忆过程。
生物活性

[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1].

体外研究
(In Vitro)

[DPro5] Corticotropin Releasing Factor, human, rat (1 nM; 1 h) diminishes the amplitude of hippocampal population spike and prevents the onset of long-term potentiation (LTP)[2].

体内研究
(In Vivo)

[DPro5] Corticotropin Releasing Factor, human, rat (0.01-1 μg; i.c.v.; single dose) doesn’t induce the typical anxiogenic effect, but produces a nonspecific suppression of behavior in Sprague-Dowley rats. And [DPro5] Corticotropin Releasing Factor, human, rat also enhances the short-term memory to a maximum degree and prevented the memory loss induced by diazepam[1].

Animal Model:Sprague-Dowley rats[1]
Dosage:0.01-1 μg
Administration:Intracerebroventricular injection; single dose
Result:Decreased the number of visits into the light box in the dark-light test.
分子量

4757.45

Formula

C208H344N60O63S2

CAS 号

195628-97-8

Sequence Shortening

SEEP-{d-Pro}-ISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.