α-Helical Corticotropin Releasing Factor (9-41) 是 corticotropin releasing factor(CRF)的拮抗剂。α-Helical Corticotropin Releasing Factor (9-41) 能够降低体内血浆生长激素 (GH) 的水平。
| 生物活性 | α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor(CRF)antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo[1][2]. |
体内研究
(In Vivo) | α-Helical Corticotropin Releasing Factor (9-41) (10 μg; the third or lateral ventricle of the brain injection; once) significantly decreases plasma GH values[1].α-Helical Corticotropin Releasing Factor (9-41) (100 ng/kg; i.c.v. once) affects rhlL-1/β-induced enhancement of the splenic sympathetic activity[2].
| Animal Model: | Adult Sprague-Dawley rats[1] | | Dosage: | 10 μg | | Administration: | The third or lateral ventricle of the brain injection; 10 μg once | | Result: | Abolished the 10 min electroshocks-produced the decreasing of plasma GH levels by injected into the third or lateral ventricle of the brain 45 min before exposure to stress. |
| Animal Model: | Adult Sprague-Dawley rats with immunity of endogenous somatostatin (SS)[1] | | Dosage: | 10 μg | | Administration: | Lateral ventricle brain injection; 10 μg once | | Result: | Showed no effect on plasma GH values in rats whose endogenous SS had been immunoneutralized, but did interfere with the stimulatory effect of GH-releasing factor (GRF). |
| Animal Model: | Male Wistar rats with rhlL-1/β injection[2] | | Dosage: | 100 ng/kg | | Administration: | Intracerebroventricularly injection; 100 ng/kg once | | Result: | Completely blocked the rhlL-1/β-induced enhancement of the splenic sympathetic activity, but failed to alter the enhancement of nociceptive behaviors caused by rhlL-1/β. |
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| 分子量 | |
| Formula | |
| CAS 号 | |
| Sequence Shortening | DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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