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Dexamethasone(DHAP)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dexamethasone(DHAP)图片
CAS NO:50-02-2
规格:≥98%
包装与价格:
包装价格(元)
1g电议
2g电议
5g电议
10g电议
25g电议
50g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)392.46
FormulaC22H29FO5
CAS No.50-02-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 79 mg/mL (201.3 mM)
Water: <1 mg/mL
Ethanol: 6 mg/mL (15.3 mM)
Solubility (In vivo)30% PEG400+0.5% Tween80+5% Propylene glycol: 30mg/kg
SynonymsHexadecadrol; Prednisolone F; Decaject; Decaject L.A.; Decaject-L.A.; Decameth; Decaspray; Dexasone; Dexpak; Hexadrol.; Maxidex; Methylfluorprednisolone; Millicorten; Oradexon
实验参考方法
In Vitro

In vitro activity: Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG.

In VivoDexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls.
Animal model
Formulation & Dosage
References

Neurosci Lett. 2003 Jun 26;344(2):112-6; J Physiol. 2003 Feb 15;547(Pt 1):61-6.