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Bam-12P
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:75513-71-2
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
BAM-12P 是一种内源性阿片肽，一种新型前甲硫氨酸脑啡肽。BAM-12P 可以激活人 κ-阿片受体 (hKOR)，EC50为 101 nM，pEC50为 6.99。BAM-12P 是CXCR7的配体，EC50为 175 nM。
生物活性

BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activatehuman κ-opioid receptor (hKOR)with anEC50of 101 nM and apEC50of 6.99. BAM-12P is a ligand forCXCR7with anEC50of 175 nM[1][2][3].

IC50& Target[1][2]

human κ-opioid receptor (hKOR)

101 nM (EC50)

human κ-opioid receptor (hKOR)

6.99 (pEC50)

CXCR7

175 nM (EC50)

体外研究
(In Vitro)

BAM-12P 在豚鼠回肠试验中显示出有效的阿片活性，IC50为 15.5 nM[2]。

分子量

1424.63

Formula

C62H97N21O16S

CAS 号

75513-71-2

Sequence Shortening

YGGFMRRVGRPE

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.