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Demecarium Bromide(BC-48)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Demecarium Bromide(BC-48)图片
CAS NO:56-94-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议

产品介绍
Demecarium Bromide (BC-48) (BC-48) 是一种有效的胆碱酯酶抑制剂,表观亲和力 (Kiapp) 为 0.15 μM.
Cas No.56-94-0
别名地美溴铵; BC-48
Canonical SMILESO=C(N(CCCCCCCCCCN(C(OC1=CC([N+](C)(C)C)=CC=C1)=O)C)C)OC2=CC([N+](C)(C)C)=CC=C2.[Br-].[Br-]
分子式C32H52Br2N4O4
分子量716.59
溶解度DMSO : 160 mg/mL (223.28 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Demecarium Bromide (BC-48) is a potent cholinesterase antagonist, with an apparent affinity (Kiapp) of 0.15 μM[1]. Demecarium Bromide (BC-48) is used as a glaucoma agent[2].

Demecarium Bromide (0.125 and 0.5%) causes long-term miosis and decreases intraocular pressure (IOP) in beagles with both normotensive eyes and inherited glaucoma[1].

[1]. Brown JH, et al. Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. J Pharmacol Exp Ther. 1982 Oct;223(1):20-4. [2]. Gum GG, et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54(2):287-93.