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NUCC-390
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NUCC-390图片
CAS NO:1060524-97-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
NUCC-390 是新型的选择性小分子CXCR4 receptor受体激动剂。NUCC-390 可以诱导 CXCR4 受体的内化,作用方式与 AMD3100 (HY-10046) 相反。NUCC-390 在动物模型中,有助于神经退行性变后神经功能恢复。
生物活性

NUCC-390 is a novel and selective small-moleculeCXCR4receptoragonist. NUCC-390 induces internalization ofCXCR4receptors and acts in an opposite way of AMD3100 (HY-10046)[1][2]. NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo[2].

IC50& Target[1]

CXCR4

 

体外研究
(In Vitro)

NUCC-390 (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100[1].
NUCC-390 (10 μM; pre-treatment 30 mins) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors[1].
NUCC-390 (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non-treated cells exhibit some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells[1].
NUCC-390 (0-1.25 μM; 24 hours) boosts axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4[2].

Western Blot Analysis[1]

Cell Line:C8161 cells
Concentration:10 μM
Incubation Time:Pre-treated 30 mins
Result:Increased the level of pERK.

Cell Proliferation Assay[2]

Cell Line:Cerebellar granule neurons (CGNs)
Concentration:0 μM; 0.0625 μM; 0.25 μM; 1.25 μM
Incubation Time:24 hours
Result:Stimulated axonal growth via CXCR4.
体内研究
(In Vivo)

NUCC-390 (hind limb injection; 3.2 mg/kg; twice daily; 3 days) contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice[2].

Animal Model:Six to eight-week-old CD1 mice[2]
Dosage:3.2 mg/kg
Administration:Hind limb injection; twice daily; 3 days
Result:Promoted functional and anatomical recovery of the NMJ.
分子量

395.54

Formula

C23H33N5O

CAS 号

1060524-97-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.