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CTCE-9908
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1030384-98-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
CTCE-9908 是一种有效的,选择性的CXCR4抑制剂。CTCE-9908 在表达 CXCR4 的卵巢癌细胞中诱导有丝分裂突变,诱导细胞毒性,抑制迁移。
生物活性

CTCE-9908 is a potent and selectiveCXCR4antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovariancancercells[1][2].

IC50& Target[1]

CXCR4

 

体外研究
(In Vitro)

CTCE-9908 (0-300 μg/mL; for 10 d) inhibits migration and growth in CXCR4-expressing in ovarian cancer cell lines (IGROV, TOV21G and SKOV3). CTCE-9908 inhibits ovarian cancer cell migration to CXCL12. CTCE-9908 does not cause apoptosis or cellular senescence, but induces multinucleation, G2-M arrest, and abnormal mitosis in ovarian cancer cells. CTCE-9908 deregulates DNA damage checkpoint proteins and spindle assembly checkpoint proteins at G2-M phases of the cell cycle[1].

体内研究
(In Vivo)

CTCE-9908 (25, 50 and 100 mg/kg; s.c.; 5 days per week for 4.5 weeks) alone slows the rate of primary breast tumor growth, with a 45% inhibition of primary tumor growth at 3.5 weeks of treatment with 50 mg/kg in FVB/N TgN (MMTV-PyMT)634male mice[2].

分子量

1927.25

性状

Solid

Formula

C86H147N27O23

CAS 号

1030384-98-5

Sequence Shortening

Sequence 1:KGVSLSYRK-NH2;Sequence 1':KGVSLSYR (Amide bridge:Lys9-Arg8’)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Stored under nitrogen, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

溶解性数据
In Vitro: 

H2O : 33.33 mg/mL(17.29 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.5189 mL2.5944 mL5.1887 mL
5 mM0.1038 mL0.5189 mL1.0377 mL
10 mM0.0519 mL0.2594 mL0.5189 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (stored under nitrogen, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。